Allopurinol-thiopurine combination therapy in inflammatory bowel disease: are there genetic clues to this puzzle?
نویسندگان
چکیده
Margien L Seinen*,1, Nanne KH de Boer1, Adriaan A van Bodegraven1,2, Stephen B Hanauer3 & Frank Hoentjen4 Department of Gastroenterology, VU University Medical Center, Amsterdam, The Netherlands Department of Internal Medicine, Gastroenterology & Geriatrics, ORBIS Medical Center, The Netherlands Digestive Health Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Inflammatory Bowel Disease Center, Radboud University Medical Center, Nijmegen, The Netherlands *Author for correspondence: Tel.: +31 20 444 0613 Fax: +31 20 444 0554 [email protected]
منابع مشابه
Successful Pregnancies with Thiopurine-Allopurinol Co-Therapy for Inflammatory Bowel Disease.
BACKGROUND Thiopurines are an effective treatment for moderate to severe inflammatory bowel disease [IBD] and can be used safely in pregnancy. Combining allopurinol with a lower dose of thiopurine can improve clinical efficacy and bypass some adverse reactions associated with thiopurine monotherapy. Data on allopurinol in pregnancy are scarce. We report on a total of 13 cases where thiopurine a...
متن کاملThe effect of allopurinol and low-dose thiopurine combination therapy on the activity of three pivotal thiopurine metabolizing enzymes: results from a prospective pharmacological study.
INTRODUCTION Thiopurine therapy is often discontinued in inflammatory bowel disease (IBD) patients. The xanthine oxidase (XO) inhibitor allopurinol has previously shown to enhance thiopurine efficacy and to prevent adverse reactions, the mechanism of this beneficial interaction is not completely clarified. The aim of this study is to observe possible effects of allopurinol and low-dose thiopuri...
متن کاملAllopurinol in combination with thiopurine induces mucosal healing and improves clinical and metabolic outcomes in IBD
Background Thiopurines, azathioprine (AZA) and 6-mercaptopurine (6-MP) are common maintenance medications for inflammatory bowel disease (IBD). Excessive methylation via thiopurine methyltransferase (TPMT) frequently causes therapeutic failure. Allopurinol reduces excessive 6-methyl-mercaptopurine (6-MMP) while enhancing 6-thioguanine (6-TGN) levels. The aim of this study was to evaluate clinic...
متن کاملLow-dose azathioprine or mercaptopurine in combination with allopurinol can bypass many adverse drug reactions in patients with inflammatory bowel disease.
BACKGROUND The thiopurine drugs, azathioprine and mercaptopurine (MP), are established treatments for IBD. However, therapeutic failure caused by adverse drug reactions occurs frequently. AIM To study combination of allopurinol with reduced-dose thiopurine in an attempt to avoid adverse drug reactions in the treatment of IBD. METHODS Patients with drug reactions to full-dose thiopurines wer...
متن کاملOptimizing Thiopurine Therapy in Inflammatory Bowel Disease Among 2 Real-life Intercept Cohorts: Effect of Allopurinol Comedication?
BACKGROUND Thiopurines (azathioprine and mercaptopurine) are frequently used immunosuppressive drugs to maintain remission in patients with inflammatory bowel disease. Half of the conventional thiopurine-derivative users have to discontinue treatment within 5 years, mainly because of intolerable adverse events. Over recent years, different strategies to optimize thiopurine treatment were sugges...
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ورودعنوان ژورنال:
- Pharmacogenomics
دوره 11 11 شماره
صفحات -
تاریخ انتشار 2010